Similac Advance vs Pro Advance: Which Formula is Right for Your Baby? A Comprehensive Comparison

Breastfeeding is the best option for a kid. However, when circumstances and conditions don’t allow it, infant formula milk is the next best alternative.

But you don’t need to fall for any formula milk. Instead, you need a brand that provides complete nutrition for the baby. However, its composition should have a close resemblance to breastmilk.

Disclaimer: This post might contain affiliate links. In case you buy through these links, we might receive a small commission, which helps us operate this website. Learn more here.

And that’s where Similac Advance and Similac Pro Advance come in. So close are the two infant formula milk that some mothers can’t tell their differences.

The post hence brings out the comparison of Similac Advance vs Pro advances. Read on to learn their similarities and differences.

Summary of Similac Advance vs Pro Advance

TitleComplete NutritionHas OptiGO (DHA, Vitamin E, and Lutein)No Palm Olein OilFortified with IronHas 2′ – FL HMOFree from GMO
Similac AdvanceYesYesYesYesNoNo
Pro AdvanceYesYesYesYesYesYes

Similac Advance

Similac advance is an infant formula milk with a complete nutritional component. It targets babies from birth to one year old. Besides Similac advance has the following features:

Simple to Digest

The Simple Advance formula milk is easy to digest by infants. It’s suitable for infants right from birth to 12 months.

Nutritionally Complete

Similac Advance has a close resemblance to breast milk. It comprises vital nutrients, and so provides a nutritionally complete diet. The valuable nutrients include protein, vitamins, carbohydrates, fat, and minerals infants need.


As nutritionally complete infant milk, Similac Advance comprises a unique blend of nutrients called OptiGro. That includes a mixture of DHA, Vitamin E, and lutein.

The three ingredients are abundant in breast milk and help in eye and brain development.

No Palm Olein Oil

The manufacturer of Similac advance states that the baby formula milk has no traces of palm olein milk. And, due to the absence of palm olein oil, Similac advance supports efficient absorption of calcium and passing out of the soft stool.

No Artificial Growth Hormone

Another feature that singles out Similac advance is that its ingredients have no artificial growth hormone.

Not Recommended for Babies with Galactosemia

Since Similac Advance has lactose, it isn’t fit for babies suffering from galactosemia. Galactosemia victims find it difficult to process lactose.

Shop on

Similac Pro Advance

Similac Pro Advance is also another nutritionally complete formula milk. However, it has few but tangible differences with Similac advance. Pro Advance has top features that include the following.

Unique Opti GRO Blend

Its formulation has a unique blend of nutrients called OptiGRO. That includes a mixture of DHA, Lutein and vitamin E. here is a breakdown of the role of each nutrient in the OptiGRO

  • DHA helps in brain development
  • Lutein assists in eye development
  • Vitamin E plays a crucial role in developing cells

Therefore, Similac Pro advances help in the proper development of the eye, brain, and cells

No Palm Olein Oil

Similac Pro Advance baby formula’s composition doesn’t include palm olein oil. Thus, you can rest assured that your baby’s stool will be soft.

Your infant’s body can then absorb calcium effectively from the infant milk.

Complete Nutrition for Infants

Pro advance packs all the valuable nutrients that the developing child needs. The nutrients include vitamins, carbohydrates, protein, and even fats.


All ingredients in the Similac Pro advanced doesn’t come from genetically engineered animals or plants. Therefore, you can consider it pure infant milk.

Some parents fear consuming food coming from genetically engineered plants and animals.

Has 2-FL HMO

One distinguishing feature of the Similac Pro advance is that it’s rich in 2′-FL human milk oligosaccharide, 2′-FL HMO.

The human milk oligosaccharide is a probiotic responsible for nourishing the immune system.

Shop on

Similarities and Differences Between Similac Advance Vs. Pro Advance

In the Similac Advance vs Pro advance comparison, the following similarities come out:

Similarities Between Similac Advance and Pro Advance Infant Formula Milk

Both Contain OptiGRO

That is a blend of vitamin E, lutein, and DHA. The mixture assists in eye and brain development.

Does Not Contain Palm Olein Oil

None of the two-formula milk has palm olein oil. Palm olein oil discourages the proper absorption of calcium.

Correct Iron Ratio

Each formula has iron in the ratio of 1.8mg per 100 calories. Such a percentage meets the FDA requirement of 1 mg per 100 calories.

Not Fit for Galactosemia Victims

Similac advance and Pro advance aren’t fit for persons with galactosemia. Children suffering from the condition cannot digest lactose.

Meant for Babies 12 Months and Below

Both infant formula milk targets babies from birth to 12 months old.

Differences Between Similac Advance and Pro Advance

In the Similac Advance and Pro advance comparison, the following are the tangible differences;

Pro Advance Rich in 2′ – FL HMO

The Similac Advance infant formula milk is rich in the 2′ – FL HMO (human milk oligosaccharide). It’s abundant in breast milk and helps in building a proper immune system.

On the other hand, Similac Advance lacks the 2′ – FL HMO.

Similac Advance has GMO Ingredients and Pro Advance is GMO-Free

A fraction of the ingredients that make up Similac Advance come from genetically engineered plants or animals. But Pro Advance is free from genetically modified organisms.

And being free from GMOs, Pro Advance has fewer chances of causing allergies and building up resistance against allergies. Furthermore, it aids in preserving internal organs.


Concerning the price tag, Pro advance attracts a slightly higher cost than Similac advance. Most probably it’s due to the additional ingredients in the pro advance.

However, the price difference isn’t that significant to sway your decision to one side.


Past users suggest that Similac advance registers a different smell from Pro advance. Many people claim that Similac Pro Advance has a barely noticeable smell that its counterpart.

On the other hand, Similac advance produces a tin-like smell. Infants who are sensitive to smell may have slight difficulties using Similac advance.

Therefore, in the Comparison of Similac Advance Vs. Pro Advance, which one should you choose?

The two infant formula milk provides the complete nutrition babies require for the first 12 months. Therefore, Similac Advance or Pro Advance may work for you.

But if you need infant formula milk for the budget, Similac Advance wins. On the other hand, if you need baby formula milk that’s free from GMOs and rich in immunity-nourishing prebiotics, Pro Advance wins.

Spread the love